Drug-resistant tuberculosis (TB) with or without associated HIV, is making a tremendous resurgence in Africa, and Eastern Europe and Russia. These are all usually resistant to first-line medication and most are also resistant to second-line.
This is obviously a major socio-political issue, as we see in our daily practice. Not only is there an increase in the incidence of tuberculosis, the organ systems involved and the patterns of involvement have changed and become more complex. M. tuberculosus unfortunately does not read our text-books.
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